The Mathcad UI is like a whiteboard. It executes from top left to bottom right. There are no pages, let alone columns. The dashed lines you see for pages apply only to printing, not to the way the document calculates. It is possible to simulate what you want, in a limited way, by creating two text regions, one on the left of a "page" and one on the right. Then insert math in the text regions as needed. You can't insert graphs or anything else though, only text and math, so this approach is rather limited.
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