We have a replicator 2x and Creo Parametric 2.0. Creo makes the .stl file that will go directly into the Makerware software provided by Makerbot. This is smooth and works well.
I would not recommend the replicator 2x machine that we have, the end parts do not come out dimensionally correct. We generally have to print, measure, scale and print a 2nd time to get it right. I think the replicator 2 you mentioned will be a better machine as it prints PLA which is more stable.